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Genome-wide association study in Chinese cohort identifies one novel hypospadias risk associated locus at 12q13.13.

ABSTRACT: BACKGROUND:Hypospadias risk-associated gene variants have been reported in populations of European descent using genome-wide association studies (GWASs). There is little known at present about any possible hypospadias risk associations in Han Chinese populations. METHODS:To systematically investigate hypospadias risk-associated gene variants in Chinese patients, we performed the first GWAS in a Han Chinese cohort consisting of 197 moderate-severe hypospadias cases and 933 unaffected controls. Suggestive loci (p?

SUBMITTER: Chen Z 

PROVIDER: S-EPMC6923877 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature

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Genome-wide association study in Chinese cohort identifies one novel hypospadias risk associated locus at 12q13.13.

Chen Zhongzhong Z   Lin Xiaoling X   Lei Yunping Y   Chen Haitao H   Finnell Richard H RH   Wang Yaping Y   Xu Jianfeng J   Lu Daru D   Xie Hua H   Chen Fang F  

BMC medical genomics 20191219 1

<h4>Background</h4>Hypospadias risk-associated gene variants have been reported in populations of European descent using genome-wide association studies (GWASs). There is little known at present about any possible hypospadias risk associations in Han Chinese populations.<h4>Methods</h4>To systematically investigate hypospadias risk-associated gene variants in Chinese patients, we performed the first GWAS in a Han Chinese cohort consisting of 197 moderate-severe hypospadias cases and 933 unaffect  ...[more]

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