Ontology highlight
ABSTRACT:
SUBMITTER: Fischer NO
PROVIDER: S-EPMC2918428 | biostudies-literature | 2010 Jun
REPOSITORIES: biostudies-literature
Fischer Nicholas O NO Infante Ernesto E Ishikawa Tomohiro T Blanchette Craig D CD Bourne Nigel N Hoeprich Paul D PD Mason Peter W PW
Bioconjugate chemistry 20100601 6
Subunit antigens are attractive candidates for vaccine development, as they are safe, cost-effective, and rapidly produced. Nevertheless, subunit antigens often need to be adjuvanted and/or formulated to produce products with acceptable potency and efficacy. Here, we describe a simple method for improving the potency and efficacy of a recombinant subunit antigen by its immobilization on nickel-chelating nanolipoprotein particles (NiNLPs). NiNLPs are membrane mimetic nanoparticles that provide a ...[more]