Ontology highlight
ABSTRACT:
SUBMITTER: Bernstein SL
PROVIDER: S-EPMC2918915 | biostudies-literature | 2009 Jul
REPOSITORIES: biostudies-literature
Bernstein Summer L SL Dupuis Nicholas F NF Lazo Noel D ND Wyttenbach Thomas T Condron Margaret M MM Bitan Gal G Teplow David B DB Shea Joan-Emma JE Ruotolo Brandon T BT Robinson Carol V CV Bowers Michael T MT
Nature chemistry 20090701 4
In recent years, small protein oligomers have been implicated in the aetiology of a number of important amyloid diseases, such as type 2 diabetes, Parkinson's disease and Alzheimer's disease. As a consequence, research efforts are being directed away from traditional targets, such as amyloid plaques, and towards characterization of early oligomer states. Here we present a new analysis method, ion mobility coupled with mass spectrometry, for this challenging problem, which allows determination of ...[more]