Ontology highlight
ABSTRACT:
SUBMITTER: Liang G
PROVIDER: S-EPMC2919115 | biostudies-literature | 2010 Aug
REPOSITORIES: biostudies-literature
Liang Gaoyang G Taranova Olena O Xia Kai K Zhang Yi Y
The Journal of biological chemistry 20100616 33
Recent studies have demonstrated that embryonic stem cell-like induced pluripotent stem (iPS) cells can be generated by enforced expression of defined transcription factors. The fact that cell fate change is accompanied by changes in epigenetic modifications prompted us to investigate whether chemicals known to modulate epigenetic regulators are capable of enhancing the efficiency of iPS cell generation. Here, we report that butyrate, a natural small fatty acid and histone deacetylase inhibitor, ...[more]