Ontology highlight
ABSTRACT:
SUBMITTER: Liang G
PROVIDER: S-EPMC3544197 | biostudies-literature | 2012 Apr
REPOSITORIES: biostudies-literature
Liang Gaoyang G He Jin J Zhang Yi Y
Nature cell biology 20120422 5
Transcription-factor-directed reprogramming from somatic cells to induced pluripotent stem cells (iPSCs) is by nature an epigenetic process of cell fate change. Previous studies have demonstrated that this inefficient process can be facilitated by the inclusion of additional factors. To gain insight into the reprogramming mechanism, we aimed to identify epigenetic enzymes capable of promoting iPSC generation. Here we show that Kdm2b, a histone H3 Lys 36 dimethyl (H3K36me2)-specific demethylase, ...[more]