Ontology highlight
ABSTRACT:
SUBMITTER: Moyal L
PROVIDER: S-EPMC3397146 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
Moyal Lilach L Lerenthal Yaniv Y Gana-Weisz Mali M Mass Gilad G So Sairei S Wang Shih-Ya SY Eppink Berina B Chung Young Min YM Shalev Gil G Shema Efrat E Shkedy Dganit D Smorodinsky Nechama I NI van Vliet Nicole N Kuster Bernhard B Mann Matthias M Ciechanover Aaron A Dahm-Daphi Jochen J Kanaar Roland R Hu Mickey C-T MC Chen David J DJ Oren Moshe M Shiloh Yosef Y
Molecular cell 20110301 5
The cellular response to DNA double-strand breaks (DSBs) is mobilized by the protein kinase ATM, which phosphorylates key players in the DNA damage response (DDR) network. A major question is how ATM controls DSB repair. Optimal repair requires chromatin relaxation at damaged sites. Chromatin reorganization is coupled to dynamic alterations in histone posttranslational modifications. Here, we show that in human cells, DSBs induce monoubiquitylation of histone H2B, a modification that is associat ...[more]