Ontology highlight
ABSTRACT:
SUBMITTER: Gold B
PROVIDER: S-EPMC2921703 | biostudies-literature | 2006 Apr
REPOSITORIES: biostudies-literature
Gold Bert B Merriam Joanna E JE Zernant Jana J Hancox Lisa S LS Taiber Andrew J AJ Gehrs Karen K Cramer Kevin K Neel Julia J Bergeron Julie J Barile Gaetano R GR Smith R Theodore RT Hageman Gregory S GS Dean Michael M Allikmets Rando R
Nature genetics 20060305 4
Age-related macular degeneration (AMD) is the most common form of irreversible blindness in developed countries. Variants in the factor H gene (CFH, also known as HF1), which encodes a major inhibitor of the alternative complement pathway, are associated with the risk for developing AMD. Here we test the hypothesis that variation in genes encoding other regulatory proteins of the same pathway is associated with AMD. We screened factor B (BF) and complement component 2 (C2) genes, located in the ...[more]