Ontology highlight
ABSTRACT:
SUBMITTER: Abrunhosa-Thomas I
PROVIDER: S-EPMC2921993 | biostudies-literature | 2010 Jun
REPOSITORIES: biostudies-literature
Abrunhosa-Thomas Isabelle I Coudray Laëtitia L Montchamp Jean-Luc JL
Tetrahedron 20100601 26
The preparation and reactivity of some α,α-difluorophosphinates is investigated. Alkylation of H-phosphinates with LiHMDS and ClCF(2)H gives the corresponding α,α-difluorophosphinates in good yield. Deprotonation of these reagents with alkyllithium or LDA is then studied. Subtle electronic effects translate into significant differences in the deprotonation/alkylation of the two "Ciba-Geigy reagents" (EtO)(2)CRP(O)(OEt)H (R = H, Me). On the other hand, attempted methylation of difluoromethyl-octy ...[more]