Differential expression of genes in elastase-induced saccular aneurysms with high and low aspect ratios.
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ABSTRACT:
SUBMITTER: Kadirvel R
PROVIDER: S-EPMC2922053 | biostudies-literature | 2010 Mar
REPOSITORIES: biostudies-literature
Publications
Differential expression of genes in elastase-induced saccular aneurysms with high and low aspect ratios.
Kadirvel Ramanathan R Ding Yong-Hong YH Dai Daying D Lewis Debra A DA Kallmes David F DF
Neurosurgery 20100301 3
<h4>Background</h4>Morphologic features are thought to play a critical role in the rupture of intracranial, saccular aneurysms.<h4>Objective</h4>The objective of this study was to investigate the gene expression pattern of saccular aneurysms with distinct morphologic patterns.<h4>Methods</h4>Elastase-induced saccular aneurysms with high (>or= 2.4) and low (<or= 1.6) aspect ratios (ARs) (height to neck width) were created in 15 rabbits (n = 9 for high AR and n = 6 for low AR). RNA was isolated fr ...[more]
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