Ontology highlight
ABSTRACT:
SUBMITTER: Li H
PROVIDER: S-EPMC2922261 | biostudies-literature | 2010 Aug
REPOSITORIES: biostudies-literature
Li Hongliang H He Chengwei C Feng Jinhua J Zhang Yan Y Tang Qizhu Q Bian Zhouyan Z Bai Xue X Zhou Heng H Jiang Hong H Heximer Scott P SP Qin Mu M Huang He H Liu Peter P PP Huang Congxin C
Proceedings of the National Academy of Sciences of the United States of America 20100719 31
The development of cardiac hypertrophy in response to increased hemodynamic load and neurohormonal stress is initially a compensatory response that may eventually lead to ventricular dilation and heart failure. Regulator of G protein signaling 5 (Rgs5) is a negative regulator of G protein-mediated signaling by inactivating Galphaq and Galphai, which mediate actions of most known vasoconstrictors. Previous studies have demonstrated that Rgs5 expresses among various cell types within mature heart ...[more]