Ontology highlight
ABSTRACT:
SUBMITTER: Whittle JR
PROVIDER: S-EPMC2922654 | biostudies-literature | 2010 Aug
REPOSITORIES: biostudies-literature
Whittle James R R JR Schwartz Thomas U TU
The Journal of cell biology 20100801 3
Ancestral coatomer element 1 (ACE1) proteins assemble latticework coats for COPII vesicles and the nuclear pore complex. The ACE1 protein Sec31 and Sec13 make a 2:2 tetramer that forms the edge element of the COPII outer coat. In this study, we report that the COPII accessory protein Sec16 also contains an ACE1. The 165-kD crystal structure of the central domain of Sec16 in complex with Sec13 was solved at 2.7-A resolution. Sec16 and Sec13 also make a 2:2 tetramer, another edge element for the C ...[more]