Ontology highlight
ABSTRACT:
SUBMITTER: Reed J
PROVIDER: S-EPMC2922717 | biostudies-literature | 2007 May
REPOSITORIES: biostudies-literature
Reed Jason J Mishra Bud B Pittenger Bede B Magonov Sergei S Troke Joshua J Teitell Michael A MA Gimzewski James K JK
Nanotechnology 20070501 4
Established techniques for global gene expression profiling, such as microarrays, face fundamental sensitivity constraints. Due to greatly increasing interest in examining minute samples from micro-dissected tissues, including single cells, unorthodox approaches, including molecular nanotechnologies, are being explored in this application. Here, we examine the use of single molecule, ordered restriction mapping, combined with AFM, to measure gene transcription levels from very low abundance samp ...[more]