Ontology highlight
ABSTRACT:
SUBMITTER: Long F
PROVIDER: S-EPMC4273215 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Long Fei F Cao Bin B Khanal Ashok A Fang Shiyue S Shahbazian-Yassar Reza R
Beilstein journal of nanotechnology 20141114
Single-molecule force spectroscopy with an atomic force microscope has been widely used to study inter- and intramolecular interactions. To obtain data consistent with single molecular events, a well-defined method is critical to limit the number of molecules at the apex of an AFM probe to one or to a few. In this paper, we demonstrate an easy method for single-molecule probe modification by using the Cu-catalyzed alkyne-azide cycloaddition reaction. Excess terminal alkynes were covalently attac ...[more]