Ontology highlight
ABSTRACT:
SUBMITTER: Savage AM
PROVIDER: S-EPMC6374405 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Nature communications 20190213 1
Angiogenesis requires co-ordination of multiple signalling inputs to regulate the behaviour of endothelial cells (ECs) as they form vascular networks. Vascular endothelial growth factor (VEGF) is essential for angiogenesis and induces downstream signalling pathways including increased cytosolic calcium levels. Here we show that transmembrane protein 33 (tmem33), which has no known function in multicellular organisms, is essential to mediate effects of VEGF in both zebrafish and human ECs. We fin ...[more]