Ontology highlight
ABSTRACT:
SUBMITTER: Torregrosa RR
PROVIDER: S-EPMC2923406 | biostudies-literature | 2010 Jul
REPOSITORIES: biostudies-literature
Journal of the American Chemical Society 20100701 27
Benzyl esters of propiolic and beta-keto acids undergo catalytic decarboxylative coupling when treated with appropriate palladium catalysts. Such decarboxylative couplings allow the benzylation of alkynes without the use of strong bases and/or organometallics. This allows the synthesis of sensitive benzylic alkynes that are prone to undergo isomerizations under basic conditions. Additionally, decarboxylation facilitates the site-specific benzylation of diketones and ketoesters under mild, base-f ...[more]