Presence of a putative tumor-initiating progenitor cell population predicts poor prognosis in smokers with non-small cell lung cancer.
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ABSTRACT:
SUBMITTER: Ooi AT
PROVIDER: S-EPMC2924777 | biostudies-literature | 2010 Aug
REPOSITORIES: biostudies-literature
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Presence of a putative tumor-initiating progenitor cell population predicts poor prognosis in smokers with non-small cell lung cancer.
Ooi Aik T AT Mah Vei V Nickerson Derek W DW Gilbert Jennifer L JL Ha Vi Luan VL Hegab Ahmed E AE Horvath Steve S Alavi Mohammad M Maresh Erin L EL Chia David D Gower Adam C AC Lenburg Marc E ME Spira Avrum A Solis Luisa M LM Wistuba Ignacio I II Walser Tonya C TC Wallace William D WD Dubinett Steven M SM Goodglick Lee L Gomperts Brigitte N BN
Cancer research 20100801 16
Smoking is the most important known risk factor for the development of lung cancer. Tobacco exposure results in chronic inflammation, tissue injury, and repair. A recent hypothesis argues for a stem/progenitor cell involved in airway epithelial repair that may be a tumor-initiating cell in lung cancer and which may be associated with recurrence and metastasis. We used immunostaining, quantitative real-time PCR, Western blots, and lung cancer tissue microarrays to identify subpopulations of airwa ...[more]
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