Ontology highlight
ABSTRACT:
SUBMITTER: Ogihara NL
PROVIDER: S-EPMC29269 | biostudies-literature | 2001 Feb
REPOSITORIES: biostudies-literature
Ogihara N L NL Ghirlanda G G Bryson J W JW Gingery M M DeGrado W F WF Eisenberg D D
Proceedings of the National Academy of Sciences of the United States of America 20010201 4
Three-dimensional (3D) domain-swapped proteins are intermolecularly folded analogs of monomeric proteins; both are stabilized by the identical interactions, but the individual domains interact intramolecularly in monomeric proteins, whereas they form intermolecular interactions in 3D domain-swapped structures. The structures and conditions of formation of several domain-swapped dimers and trimers are known, but the formation of higher order 3D domain-swapped oligomers has been less thoroughly st ...[more]