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An Efficient System For the Pd-Catalyzed Cross-Coupling of Amides and Aryl Chlorides.

ABSTRACT: A catalyst based on a new biarylphosphine ligand (3) for the Pd-catalyzed cross-coupling reactions of amides and aryl chlorides is described. This system shows the highest turnover frequencies reported to date for these reactions, especially for aryl chloride substrates bearing an ortho substituent. An array of amides and aryl chlorides were successfully reacted in good to excellent yields.

SUBMITTER: Fors BP

PROVIDER: S-EPMC2927134 | biostudies-literature | 2009 Aug

REPOSITORIES: biostudies-literature

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An Efficient System For the Pd-Catalyzed Cross-Coupling of Amides and Aryl Chlorides.

Fors Brett P BP Dooleweerdt Karin K Zeng Qingle Q Buchwald Stephen L SL

Tetrahedron 20090801 33

A catalyst based on a new biarylphosphine ligand (3) for the Pd-catalyzed cross-coupling reactions of amides and aryl chlorides is described. This system shows the highest turnover frequencies reported to date for these reactions, especially for aryl chloride substrates bearing an ortho substituent. An array of amides and aryl chlorides were successfully reacted in good to excellent yields. ...[more]

PMID: 20740063

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