Ontology highlight
ABSTRACT:
SUBMITTER: Khandelwal G
PROVIDER: S-EPMC2928768 | biostudies-literature | 2010
REPOSITORIES: biostudies-literature
Khandelwal Garima G Bhyravabhotla Jayaram J
PloS one 20100826 8
We report here a novel method for predicting melting temperatures of DNA sequences based on a molecular-level hypothesis on the phenomena underlying the thermal denaturation of DNA. The model presented here attempts to quantify the energetic components stabilizing the structure of DNA such as base pairing, stacking, and ionic environment which are partially disrupted during the process of thermal denaturation. The model gives a Pearson product-moment correlation coefficient (r) of approximately ...[more]