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Pd-catalyzed carbonylative conjugate addition of dialkylzinc reagents to unsaturated carbonyls.

ABSTRACT: The Pd-catalyzed addition of organozinc reagents to unsaturated carbonyls in the presence of carbon monoxide provides 1,4-diketones in good yield. The reaction was studied with a number of substituted cyclic and acyclic ketones as well as alpha,beta-unsaturated aldehydes.

SUBMITTER: Custar DW

PROVIDER: S-EPMC2929296 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature

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Pd-catalyzed carbonylative conjugate addition of dialkylzinc reagents to unsaturated carbonyls.

Custar Daniel W DW Le Hai H Morken James P JP

Organic letters 20100901 17

The Pd-catalyzed addition of organozinc reagents to unsaturated carbonyls in the presence of carbon monoxide provides 1,4-diketones in good yield. The reaction was studied with a number of substituted cyclic and acyclic ketones as well as alpha,beta-unsaturated aldehydes. ...[more]

PMID: 20687574

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