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Saponins and a lignan derivative of Terminalia tropophylla from the Madagascar Dry Forest.

ABSTRACT: A study of an EtOH extract obtained from the roots of the Madagascan plant Terminalia tropophylla H. Perrier (Combretaceae) led to isolation of the oleanane-type triterpenoid saponin 1, the lignan derivative 2, and the two known saponins arjunglucoside I (3) and sericoside (4). The structures of compounds 1 (terminaliaside A) and 2 (4'-O-cinnamoyl cleomiscosin A) were elucidated using 1D and 2D NMR experiments and mass spectrometry. Compound 1 showed antiproliferative activity against the A2780 human ovarian cancer cell line with an IC(50) value of 1.2 microM.

SUBMITTER: Cao S

PROVIDER: S-EPMC2813959 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature

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Saponins and a lignan derivative of Terminalia tropophylla from the Madagascar Dry Forest.

Cao Shugeng S Brodie Peggy J PJ Callmander Martin M Randrianaivo Richard R Rakotobe Etienne E Rasamison Vincent E VE Kingston David G I DG

Phytochemistry 20091028 1

A study of an EtOH extract obtained from the roots of the Madagascan plant Terminalia tropophylla H. Perrier (Combretaceae) led to isolation of the oleanane-type triterpenoid saponin 1, the lignan derivative 2, and the two known saponins arjunglucoside I (3) and sericoside (4). The structures of compounds 1 (terminaliaside A) and 2 (4'-O-cinnamoyl cleomiscosin A) were elucidated using 1D and 2D NMR experiments and mass spectrometry. Compound 1 showed antiproliferative activity against the A2780 ...[more]

PMID: 19875137

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