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Antiproliferative Compounds from Ocotea macrocarpa from the Madagascar Dry Forest(1).

ABSTRACT: Bioassay-directed fractionation of an antiproliferative ethanol extract of the roots of Ocotea macrocarpa (Lauraceae) afforded the new butanolide macrocarpolide A (1), and the two new secobutanolides macrocarpolides B (2) and C (3), together with the known butanolides linderanolide B (4) and isolinderanolide (5). The structure elucidation of all compounds was carried out based on NMR and mass spectroscopic data analyses. The absolute configurations of all compounds isolated were determined by comparison of their optical rotation values with those found in literature. Compounds 1-5 showed good antiproliferative activities against the A2780 ovarian cell line, with IC50 values of 2.57 ± 0.12 (1), 1.98 ± 0.23 (2), 1.67 ± 0.05 (3), 2.43 ± 0.41 (4), and 1.65 ± 0.44 µM (5), respectively.

SUBMITTER: Liu Y

PROVIDER: S-EPMC4448737 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature

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Antiproliferative Compounds from Ocotea macrocarpa from the Madagascar Dry Forest1.

Liu Yixi Y Cheng Emily E Rakotondraibe L Harinantenaina LH Brodie Peggy J PJ Applequist Wendy W Randrianaivo Richard R Rakotondrafara Andriamalala A Ratsimbason Michel M Rasamison Vincent E VE Kingston David G I DG

Tetrahedron letters 20150601 23

Bioassay-directed fractionation of an antiproliferative ethanol extract of the roots of Ocotea macrocarpa (Lauraceae) afforded the new butanolide macrocarpolide A (1), and the two new secobutanolides macrocarpolides B (2) and C (3), together with the known butanolides linderanolide B (4) and isolinderanolide (5). The structure elucidation of all compounds was carried out based on NMR and mass spectroscopic data analyses. The absolute configurations of al ...[more]

PMID: 26034338

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