Ontology highlight
ABSTRACT:
SUBMITTER: Dmitriev SE
PROVIDER: S-EPMC2930676 | biostudies-literature | 2010 Aug
REPOSITORIES: biostudies-literature
Dmitriev Sergey E SE Terenin Ilya M IM Andreev Dmitri E DE Ivanov Pavel A PA Dunaevsky Jacov E JE Merrick William C WC Shatsky Ivan N IN
The Journal of biological chemistry 20100621 35
During translation, aminoacyl-tRNAs are delivered to the ribosome by specialized GTPases called translation factors. Here, we report the tRNA binding to the P-site of 40 S ribosomes by a novel GTP-independent factor eIF2D isolated from mammalian cells. The binding of tRNA(i)(Met) occurs after the AUG codon finds its position in the P-site of 40 S ribosomes, the situation that takes place during initiation complex formation on the hepatitis C virus internal ribosome entry site or on some other sp ...[more]