Ontology highlight
ABSTRACT:
SUBMITTER: Pietzsch J
PROVIDER: S-EPMC2931156 | biostudies-literature | 2010 Aug
REPOSITORIES: biostudies-literature
Pietzsch John J Scheid Johannes F JF Mouquet Hugo H Klein Florian F Seaman Michael S MS Jankovic Mila M Corti Davide D Lanzavecchia Antonio A Nussenzweig Michel C MC
The Journal of experimental medicine 20100802 9
The identification and characterization of conserved epitopes on the HIV-1 viral spike that are immunogenic in humans and targeted by neutralizing antibodies is an important step in vaccine design. Antibody cloning experiments revealed that 32% of all HIV-neutralizing antibodies expressed by the memory B cells in patients with high titers of broadly neutralizing antibodies recognize one or more "core" epitopes that were not defined. Here, we show that anti-core antibodies recognize a single cons ...[more]