Ontology highlight
ABSTRACT:
SUBMITTER: Tolkatchev D
PROVIDER: S-EPMC7784754 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Tolkatchev Dmitri D Kuruba Balaganesh B Smith Garry E GE Swain Kyle D KD Smith Kaitlin A KA Moroz Natalia N Williams Trenton J TJ Kostyukova Alla S AS
Protein science : a publication of the Protein Society 20201202 2
Tropomodulins are a family of important regulators of actin dynamics at the pointed ends of actin filaments. Four isoforms of tropomodulin, Tmod1-Tmod4, are expressed in vertebrates. Binding of tropomodulin to the pointed end is dependent on tropomyosin, an actin binding protein that itself is represented in mammals by up to 40 isoforms. The understanding of the regulatory role of the tropomodulin/tropomyosin molecular diversity has been limited due to the lack of a three-dimensional structure o ...[more]