Ontology highlight
ABSTRACT:
SUBMITTER: Martinot AJ
PROVIDER: S-EPMC4709180 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Martinot Amanda J AJ Farrow Mary M Bai Lu L Layre Emilie E Cheng Tan-Yun TY Tsai Jennifer H JH Iqbal Jahangir J Annand John W JW Sullivan Zuri A ZA Hussain M Mahmood MM Sacchettini James J Moody D Branch DB Seeliger Jessica C JC Rubin Eric J EJ
PLoS pathogens 20160111 1
Mycobacterium tuberculosis (Mtb) mutants lacking rv1411c, which encodes the lipoprotein LprG, and rv1410c, which encodes a putative efflux pump, are dramatically attenuated for growth in mice. Here we show that loss of LprG-Rv1410 in Mtb leads to intracellular triacylglyceride (TAG) accumulation, and overexpression of the locus increases the levels of TAG in the culture medium, demonstrating a role of this locus in TAG transport. LprG binds TAG within a large hydrophobic cleft and is sufficient ...[more]