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ABSTRACT:
SUBMITTER: Robeyns K
PROVIDER: S-EPMC2935219 | biostudies-literature | 2010 Sep
REPOSITORIES: biostudies-literature
Robeyns Koen K Herdewijn Piet P Van Meervelt Luc L
Acta crystallographica. Section F, Structural biology and crystallization communications 20100826 Pt 9
Cyclohexene nucleic acid (CeNA) building blocks can be introduced into natural DNA sequences without a large conformational influence because of the ability of the six-membered sugar ring to mimic both the C2'-endo and C3'-endo conformations of the naturally occurring ribofuranose sugar ring. The non-self-complementary DNA sequence d[GCG(xT)GCG]/d(CGCACGC) with one incorporated CeNA (xT) moiety crystallizes in two forms: orthorhombic and tetragonal. The tetragonal form, which diffracts to 3 A re ...[more]