Ontology highlight
ABSTRACT:
SUBMITTER: Ling J
PROVIDER: S-EPMC2935939 | biostudies-literature | 2010 Sep
REPOSITORIES: biostudies-literature
Journal of the American Chemical Society 20100901 36
The enediyne antitumor antibiotic maduropeptin (MDP) is produced by Actinomadura madurae ATCC 39144. The biosynthetic pathway for the 3,6-dimethylsalicylic acid moiety of the MDP chromophore is proposed to be comprised of four enzymes: MdpB, MdpB1, MdpB2, and MdpB3. Based on the previously characterized biosynthesis of the naphthoic acid moiety of neocarzinostatin (NCS), we expected a biosynthetic pathway featuring carboxylic acid activation by the MdpB2 CoA ligase immediately before its couplin ...[more]