Ontology highlight
ABSTRACT:
SUBMITTER: Strobl-Mazzulla PH
PROVIDER: S-EPMC2939072 | biostudies-literature | 2010 Sep
REPOSITORIES: biostudies-literature
Strobl-Mazzulla Pablo Hernan PH Sauka-Spengler Tatjana T Bronner-Fraser Marianne M
Developmental cell 20100901 3
The neural crest is a multipotent stem cell-like population that is induced during gastrulation, but only acquires its characteristic morphology, migratory ability, and gene expression profile after neurulation. This raises the intriguing possibility that precursors are actively maintained by epigenetic influences in a stem cell-like state. Accordingly, we report that dynamic histone modifications are critical for proper temporal control of neural crest gene expression in vivo. The histone demet ...[more]