Ontology highlight
ABSTRACT:
SUBMITTER: Soriani M
PROVIDER: S-EPMC2943275 | biostudies-literature | 2010 Sep
REPOSITORIES: biostudies-literature
Soriani Marco M Petit Pierre P Grifantini Renata R Petracca Roberto R Gancitano Giovanni G Frigimelica Elisabetta E Nardelli Filomena F Garcia Christel C Spinelli Silvia S Scarabelli Guido G Fiorucci Sebastien S Affentranger Roman R Ferrer-Navarro Mario M Zacharias Martin M Colombo Giorgio G Vuillard Laurent L Daura Xavier X Grandi Guido G
The Journal of biological chemistry 20100630 39
We present an interdisciplinary approach that, by incorporating a range of experimental and computational techniques, allows the identification and characterization of functional/immunogenic domains. This approach has been applied to ArtJ, an arginine-binding protein whose orthologs in Chlamydiae trachomatis (CT ArtJ) and pneumoniae (CPn ArtJ) are shown to have different immunogenic properties despite a high sequence similarity (60% identity). We have solved the crystallographic structures of CT ...[more]