Ontology highlight
ABSTRACT:
SUBMITTER: Zost SJ
PROVIDER: S-EPMC6452323 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Zost Seth J SJ Wu Nicholas C NC Hensley Scott E SE Wilson Ian A IA
The Journal of infectious diseases 20190401 Suppl_1
Influenza viruses routinely acquire mutations in their hemagglutinin (HA) and neuraminidase (NA) glycoproteins that abrogate binding of pre-existing antibodies in a process known as antigenic drift. Most human antibodies against HA and NA are directed against epitopes that are hypervariable and not against epitopes that are conserved among different influenza virus strains. Universal influenza vaccines are currently being developed to elicit protective responses against functionally conserved si ...[more]