Ontology highlight
ABSTRACT:
SUBMITTER: Zhou H
PROVIDER: S-EPMC2943300 | biostudies-literature | 2010 Sep
REPOSITORIES: biostudies-literature
Zhou Hongyan H Li Wenlin W Zhu Saiyong S Joo Jin Young JY Do Jeong Tae JT Xiong Wen W Kim Jeong Beom JB Zhang Kang K Schöler Hans R HR Ding Sheng S
The Journal of biological chemistry 20100812 39
Epiblast stem cells (EpiSCs) are pluripotent cells derived from post-implantation late epiblasts in vitro. EpiSCs are incapable of contributing to chimerism, indicating that EpiSCs are less pluripotent and represent a later developmental pluripotency state compared with inner cell mass stage murine embryonic stem cells (mESCs). Using a chemical approach, we found that blockage of the TGFβ pathway or inhibition of histone demethylase LSD1 with small molecule inhibitors induced dramatic morphologi ...[more]