Ontology highlight
ABSTRACT:
SUBMITTER: Takehara T
PROVIDER: S-EPMC4588589 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Takehara Toshiyuki T Teramura Takeshi T Onodera Yuta Y Frampton John J Fukuda Kanji K
Scientific reports 20150930
The cell adhesion molecule Cadherin 2 (Cdh2) plays important roles in somatic cell adhesion, proliferation and migration. Cdh2 is also highly expressed in mouse epiblast stem cells (mEpiSCs), but its function in these cells is unknown. To understand the function of Cdh2 in mEpiSCs, we compared the expression of pluripotency-related genes in mEpiSCs and mouse embryonic stem cells (mESCs) after either Cdh2 knockdown or Cdh2 over-expression. Introduction of specific siRNA against Cdh2 led to attenu ...[more]