Ontology highlight
ABSTRACT:
SUBMITTER: Christophorou NA
PROVIDER: S-EPMC2946559 | biostudies-literature | 2010 Sep
REPOSITORIES: biostudies-literature
Christophorou Nicolas A D NA Mende Michael M Lleras-Forero Laura L Grocott Timothy T Streit Andrea A
Developmental biology 20100717 2
Crucial components of the vertebrate eye, ear and nose develop from discrete patches of surface epithelium, called placodes, which fold into spheroids and undergo complex morphogenesis. Little is known about how the changes in cell and tissue shapes are coordinated with the acquisition of cell fates. Here we explore whether these processes are regulated by common transcriptional mechanisms in the developing ear. After specification, inner ear precursors elongate to form the placode, which invagi ...[more]