Ontology highlight
ABSTRACT:
SUBMITTER: Sekulic N
PROVIDER: S-EPMC2946842 | biostudies-literature | 2010 Sep
REPOSITORIES: biostudies-literature
Sekulic Nikolina N Bassett Emily A EA Rogers Danielle J DJ Black Ben E BE
Nature 20100825 7313
Centromeres are specified epigenetically, and the histone H3 variant CENP-A is assembled into the chromatin of all active centromeres. Divergence from H3 raises the possibility that CENP-A generates unique chromatin features to mark physically centromere location. Here we report the crystal structure of a subnucleosomal heterotetramer, human (CENP-A-H4)(2), that reveals three distinguishing properties encoded by the residues that comprise the CENP-A targeting domain (CATD; ref. 2): (1) a CENP-A- ...[more]