Genetic variation in glutathione metabolism and DNA repair genes predicts survival of small-cell lung cancer patients.

ABSTRACT:

Background

Small-cell lung cancer (SCLC) carries the worst prognosis among lung cancer diagnoses. Combined radiation and chemotherapy is the standard of care; however, treatment outcomes vary. Variability in the rate at which chemotherapy agents are metabolized and in the capacity of repairing DNA damage has been hypothesized to be partly responsible for the treatment response variation. Genes in the glutathione metabolism and DNA repair pathways were tested through tag single-nucleotide polymorphisms (SNPs) to assess their association with survival in SCLC.

Patients and methods

Blood DNA from 248 patients with primary SCLC was genotyped for 419 tag SNPs from 49 genes in the glutathione and DNA repair pathways. Association analyses with patient survival were carried out at s

SUBMITTER: Sun Z 

PROVIDER: S-EPMC2946864 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature