Ontology highlight
ABSTRACT:
SUBMITTER: Ho TV
PROVIDER: S-EPMC3177197 | biostudies-literature | 2011 Sep
REPOSITORIES: biostudies-literature
Nucleic acids research 20110611 17
DNA interstrand crosslinks (ICLs), inhibit DNA metabolism by covalently linking two strands of DNA and are formed by antitumor agents such as cisplatin and nitrogen mustards. Multiple complex repair pathways of ICLs exist in humans that share translesion synthesis (TLS) past a partially processed ICL as a common step. We have generated site-specific major groove ICLs and studied the ability of Y-family polymerases and Pol ζ to bypass ICLs that induce different degrees of distortion in DNA. Two m ...[more]