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Structure of the first representative of Pfam family PF09410 (DUF2006) reveals a structural signature of the calycin superfamily that suggests a role in lipid metabolism.

ABSTRACT: The first structural representative of the domain of unknown function DUF2006 family, also known as Pfam family PF09410, comprises a lipocalin-like fold with domain duplication. The finding of the calycin signature in the N-terminal domain, combined with remote sequence similarity to two other protein families (PF07143 and PF08622) implicated in isoprenoid metabolism and the oxidative stress response, support an involvement in lipid metabolism. Clusters of conserved residues that interact with ligand mimetics suggest that the binding and regulation sites map to the N-terminal domain and to the interdomain interface, respectively.

SUBMITTER: Chiu HJ

PROVIDER: S-EPMC2954199 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature

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Structure of the first representative of Pfam family PF09410 (DUF2006) reveals a structural signature of the calycin superfamily that suggests a role in lipid metabolism.

Chiu Hsiu Ju HJ Bakolitsa Constantina C Skerra Arne A Lomize Andrei A Carlton Dennis D Miller Mitchell D MD Krishna S Sri SS Abdubek Polat P Astakhova Tamara T Axelrod Herbert L HL Clayton Thomas T Deller Marc C MC Duan Lian L Feuerhelm Julie J Grant Joanna C JC Grzechnik Slawomir K SK Han Gye Won GW Jaroszewski Lukasz L Jin Kevin K KK Klock Heath E HE Knuth Mark W MW Kozbial Piotr P Kumar Abhinav A Marciano David D McMullan Daniel D Morse Andrew T AT Nigoghossian Edward E Okach Linda L Paulsen Jessica J Reyes Ron R Rife Christopher L CL van den Bedem Henry H Weekes Dana D Xu Qingping Q Hodgson Keith O KO Wooley John J Elsliger Marc André MA Deacon Ashley M AM Godzik Adam A Lesley Scott A SA Wilson Ian A IA

Acta crystallographica. Section F, Structural biology and crystallization communications 20091208 Pt 10

The first structural representative of the domain of unknown function DUF2006 family, also known as Pfam family PF09410, comprises a lipocalin-like fold with domain duplication. The finding of the calycin signature in the N-terminal domain, combined with remote sequence similarity to two other protein families (PF07143 and PF08622) implicated in isoprenoid metabolism and the oxidative stress response, support an involvement in lipid metabolism. Clusters of conserved residues that interact with l ...[more]

PMID: 20944205

Dataset Information

Structure of the first representative of Pfam family PF09410 (DUF2006) reveals a structural signature of the calycin superfamily that suggests a role in lipid metabolism.

Publications

Structure of the first representative of Pfam family PF09410 (DUF2006) reveals a structural signature of the calycin superfamily that suggests a role in lipid metabolism.

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