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Structures of the first representatives of Pfam family PF06938 (DUF1285) reveal a new fold with repeated structural motifs and possible involvement in signal transduction.

ABSTRACT: The crystal structures of SPO0140 and Sbal_2486 were determined using the semiautomated high-throughput pipeline of the Joint Center for Structural Genomics (JCSG) as part of the NIGMS Protein Structure Initiative (PSI). The structures revealed a conserved core with domain duplication and a superficial similarity of the C-terminal domain to pleckstrin homology-like folds. The conservation of the domain interface indicates a potential binding site that is likely to involve a nucleotide-based ligand, with genome-context and gene-fusion analyses additionally supporting a role for this family in signal transduction, possibly during oxidative stress.

SUBMITTER: Han GW 

PROVIDER: S-EPMC2954208 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature

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Structures of the first representatives of Pfam family PF06938 (DUF1285) reveal a new fold with repeated structural motifs and possible involvement in signal transduction.

Han Gye Won GW   Bakolitsa Constantina C   Miller Mitchell D MD   Kumar Abhinav A   Carlton Dennis D   Najmanovich Rafael J RJ   Abdubek Polat P   Astakhova Tamara T   Axelrod Herbert L HL   Chen Connie C   Chiu Hsiu Ju HJ   Clayton Thomas T   Das Debanu D   Deller Marc C MC   Duan Lian L   Ernst Dustin D   Feuerhelm Julie J   Grant Joanna C JC   Grzechnik Anna A   Jaroszewski Lukasz L   Jin Kevin K KK   Johnson Hope A HA   Klock Heath E HE   Knuth Mark W MW   Kozbial Piotr P   Krishna S Sri SS   Marciano David D   McMullan Daniel D   Morse Andrew T AT   Nigoghossian Edward E   Okach Linda L   Reyes Ron R   Rife Christopher L CL   Sefcovic Natasha N   Tien Henry J HJ   Trame Christine B CB   van den Bedem Henry H   Weekes Dana D   Xu Qingping Q   Hodgson Keith O KO   Wooley John J   Elsliger Marc André MA   Deacon Ashley M AM   Godzik Adam A   Lesley Scott A SA   Wilson Ian A IA  

Acta crystallographica. Section F, Structural biology and crystallization communications 20100305 Pt 10

The crystal structures of SPO0140 and Sbal_2486 were determined using the semiautomated high-throughput pipeline of the Joint Center for Structural Genomics (JCSG) as part of the NIGMS Protein Structure Initiative (PSI). The structures revealed a conserved core with domain duplication and a superficial similarity of the C-terminal domain to pleckstrin homology-like folds. The conservation of the domain interface indicates a potential binding site that is likely to involve a nucleotide-based liga  ...[more]

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