Ontology highlight
ABSTRACT:
SUBMITTER: O'Hara JM
PROVIDER: S-EPMC2954487 | biostudies-literature | 2010 Oct
REPOSITORIES: biostudies-literature
O'Hara Joanne M JM Neal Lori M LM McCarthy Elizabeth A EA Kasten-Jolly Jane A JA Brey Robert N RN Mantis Nicholas J NJ
Vaccine 20100818 43
Efforts to develop an effective vaccine against ricin are focused on the engineering of attenuated and stable recombinant forms of the toxin's enzymatic A subunit (RTA). While several candidate antigens are in development, vaccine design and efficacy studies are being undertaken in the absence of a fundamental understanding of those regions of RTA that are critical in eliciting protective immunity. In this present study, we produced and characterized a collection of monoclonal antibodies (MAbs) ...[more]