Ontology highlight
ABSTRACT:
SUBMITTER: Mu W
PROVIDER: S-EPMC2957520 | biostudies-literature | 2010 Nov
REPOSITORIES: biostudies-literature
Developmental biology 20100909 2
PDCD2 is a conserved eukaryotic protein implicated in cell cycle regulation by virtue of its interactions with HCFC1 and the NCOR1/SIN3A corepressor complex. Pdcd2 transcripts are enriched in ES cells and other somatic stem cells, and its ortholog is essential for hematopoietic stem cell maintenance in Drosophila. To characterize the physiological role(s) of mammalian PDCD2, we created a disruption allele in mice. Pdcd2(-/-) embryos underwent implantation but did not undergo further development. ...[more]