Ontology highlight
ABSTRACT:
SUBMITTER: Grimes CL
PROVIDER: S-EPMC2957841 | biostudies-literature | 2010 Oct
REPOSITORIES: biostudies-literature
Grimes Catherine Leimkuhler CL Podolsky Daniel K DK O'Shea Erin K EK
Bioorganic & medicinal chemistry letters 20100817 20
Muramyl dipeptide (MDP) is believed to interact with an innate immune receptor, Nod2. To identify the cellular receptor for MDP, we have synthesized biotinylated MDP isomers and tested the ability of these compounds to activate Nod2 in a cell-based assay. We found that the modification of MDP does not perturb its ability to activate Nod2. These tagged versions of MDP will be useful to identify the cellular receptor of the immunostimulatory molecules. ...[more]