Ontology highlight
ABSTRACT:
SUBMITTER: Vershinin M
PROVIDER: S-EPMC2958055 | biostudies-literature | 2008 Jun
REPOSITORIES: biostudies-literature
Vershinin Michael M Xu Jing J Razafsky David S DS King Stephen J SJ Gross Steven P SP
Traffic (Copenhagen, Denmark) 20080328 6
We recently proposed that regulating the single-to-multiple motor transition was a likely strategy for regulating kinesin-based transport in vivo. In this study, we use an in vitro bead assay coupled with an optical trap to investigate how this proposed regulatory mechanism affects dynein-based transport. We show that tau's regulation of kinesin function can proceed without interfering with dynein-based transport. Surprisingly, at extremely high tau levels--where kinesin cannot bind microtubules ...[more]