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T-3-Benzyl-r-2,c-6-bis-(4-methoxy-phen-yl)-piperidin-4-one.

ABSTRACT: In the title compound, C(26)H(27)NO(3), the piperidine ring adopts a chair conformation. The two methoxy-phenyl groups attached to the piperidine ring at positions 2 and 6 have equatorial orientations and make a dihedral angle of 87.33?(8)°. The benzyl group at position 3 has an equatorial orientation. The phenyl ring of the benzyl group makes dihedral angles of 75.60?(9) and 73.69?(9)° with the two benzene rings. Mol-ecules are linked by inter-molecular N-H?O and C-H?O hydrogen bonds and by C-H?? inter-actions.

SUBMITTER: Jayabharathi J

PROVIDER: S-EPMC2961717 | biostudies-literature | 2008 Jun

REPOSITORIES: biostudies-literature

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t-3-Benzyl-r-2,c-6-bis-(4-methoxy-phen-yl)-piperidin-4-one.

Jayabharathi J J Thangamani A A Balamurugan S S Thiruvalluvar A A Linden A A

Acta crystallographica. Section E, Structure reports online 20080607 Pt 7

In the title compound, C(26)H(27)NO(3), the piperidine ring adopts a chair conformation. The two methoxy-phenyl groups attached to the piperidine ring at positions 2 and 6 have equatorial orientations and make a dihedral angle of 87.33 (8)°. The benzyl group at position 3 has an equatorial orientation. The phenyl ring of the benzyl group makes dihedral angles of 75.60 (9) and 73.69 (9)° with the two benzene rings. Mol-ecules are linked by inter-molecular N-H⋯O and C-H⋯O hydrogen bonds and by C-H ...[more]

PMID: 21202824

Similar Datasets

t-3-Benzyl-r-2,c-6-bis-(4-methoxy-phen-yl)piperidin-4-one oxime.

Project description:In the title mol-ecule, C(26)H(28)N(2)O(3), the piperidine ring adopts a chair conformation. The two methoxy-phenyl groups attached to the piperidine ring at positions 2 and 6 have equatorial orientations, and make a dihedral angle of 80.72?(15)°. The benzyl group at position 3 has an equatorial orientation. The oxime group at position 4 has a bi-sectional orientation. The ring of the benzyl group makes dihedral angles of 64.71?(16) and 84.79?(17)° with the two benzene rings. Mol-ecules are linked by inter-molecular N-H?O, O-H?N and C-H?O hydrogen bonds, and C-H?? inter-actions. There is also a C-H?O intra-molecular inter-action.

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Project description:In the mol-ecule of the title compound, C(20)H(23)NO(3), the bulky methoxy-phenyl substituents at the equatorial 2,6-positions crowd the vicinity of the equatorial amino H atom and prevent it from forming inter-molecular hydrogen bonds. The piperidine ring adopts a distorted chair conformation.

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Project description:The piperidone ring in the title compound, C(23)H(26)ClNO(4), adopts a boat conformation with its two out-of-plane C atoms deviating by 0.597 (2) and 0.630 (2) Å from the least-squares plane of the rest of atoms in the ring. The two aromatic rings are roughly perpendicular to each other, making a dihedral angle of 75.1 (1)°, and a C-H⋯π intra-molecular inter-action is observed. The crystal packing is stabilized by a C-H⋯O inter-molecular inter-action, generating a chain with a C(9) motif along the a axis.

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Project description:In the title compound, C(23)H(26)BrNO(4), the piperidinone ring adopts a boat conformation. The dihedral angle between the two benzene rings is 70.9 (1)°. The two meth-oxy groups are close to coplanar with the attached benzene rings [C-C-O-C torsion angles of 6.3 (5) and 16.4 (4)°]. A weak C-H⋯Br intra-molecular inter-action is observed. In the crystal structure, mol-ecules are linked into a chain along [101] by inter-molecular C-H⋯O hydrogen bonds. A short inter-molecular Br⋯O contact [3.063 (2) Å] is observed.

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2,6-Bis(4-meth-oxy-phen-yl)-1,3-dimethyl-piperidin-4-one O-benzyl-oxime.

Project description:The central ring of the title compound, C(28)H(32)N(2)O(3), exists in a chair conformation with an equatorial disposition of all the alkyl and aryl groups on the heterocycle. The para-anisyl groups on both sides of the secondary amino group are oriented at an angle of 54.75?(4)° with respect to each other. The oxime derivative exists as an E isomer with the methyl substitution on one of the active methyl-ene centers of the mol-ecule. The crystal packing features weak C-H?O inter-actions.

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1-Formyl-r-2,c-6-bis-(4-methoxy-phen-yl)-t-3-methyl-piperidin-4-one.

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1-Acetyl-t-3-ethyl-r-2,c-6-bis-(4-methoxy-phen-yl)piperidin-4-one.

Project description:In the title compound, C(23)H(27)NO(4), the piperidine ring adopts a distorted boat conformation. The meth-oxy groups lie in the plane of benzene rings to which they are attached [maximum deviations of 0.014 (3) and 0.007 (3) Å]. The benzene rings are oriented at angles of 67.2 (1) and 87.0 (1)° with respect to the best plane through the four co-planar atoms of the piperidine ring.

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r-2,c-6-Bis(3-methoxy-phen-yl)-t-3,t-5-dimethyl-piperidin-4-one.

Project description:In the title compound, C(21)H(25)NO(3), the piperidinone ring adopts a chair conformation with an equatorial orientation of all substituents; the 3-methoxy-phenyl groups make a dihedral angle of 60.26 (15)°. The carbonyl group O atom is disordered over two positions in a 0.643 (3):0.357 (3) ratio. The crystal structure is stabilized by N-H⋯O and C-H⋯O hydrogen bonding.

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r-2,c-6-Bis(4-methoxy-phen-yl)-c-3,t-3-dimethyl-piperidin-4-one.

Project description:The asymmetric unit of the title compound, C(21)H(25)NO(3), contains two crystallographically independent mol-ecules (A and B). In both mol-ecules, the piperidine ring adopts a chair conformation, with the methoxy-phenyl rings attached equatorially. The dihedral angle between the two benzene rings in mol-ecule A is 73.79 (8)°; the corresponding value in mol-ecule B is 77.71 (8)°. The mol-ecules are linked by N-H⋯O hydrogen bonds. In addition, C-H⋯π inter-actions are also found in the crystal structure.

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1-Chloro-acetyl-r-2,c-6-bis-(4-methoxy-phen-yl)-t-3-methyl-piperidin-4-one.

Project description:There are two crystallographically independent mol-ecules in the asymmetric unit of the title compound, C(22)H(24)ClNO(4). The piperidine ring in both mol-ecules adopts a distorted boat conformation. The crystal packing is stabilized by C-H?O and C-H?Cl inter-actions.

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