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Degradation of atorvastatin: (1R,2S,4S,5S)-4-(4-fluoro-phen-yl)-2-hydro-peroxy-4-hydr-oxy-2-isopropyl-N,5-diphenyl-3,6-dioxabicyclo-[3.1.0]hexane-1-carboxamide.

ABSTRACT: The degradation of atorvastatin calcium in methanol and hydrogen peroxide results in the crystallization of the title compound, C(26)H(24)FNO(6), which shows several differences compared with the starting compound. In the crystal structure of the title compound, intra- and inter-molecular hydrogen bonding is found.

SUBMITTER: Ashfaq M

PROVIDER: S-EPMC2962052 | biostudies-literature | 2008 Jul

REPOSITORIES: biostudies-literature

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Degradation of atorvastatin: (1R,2S,4S,5S)-4-(4-fluoro-phen-yl)-2-hydro-peroxy-4-hydr-oxy-2-isopropyl-N,5-diphenyl-3,6-dioxabicyclo-[3.1.0]hexane-1-carboxamide.

Ashfaq Muhammad M Tahir Muhammad Nawaz MN Khan Islam Ullah IU Iqbal Mohammad S MS Arshad Muhammad Nadeem MN

Acta crystallographica. Section E, Structure reports online 20080719 Pt 8

The degradation of atorvastatin calcium in methanol and hydrogen peroxide results in the crystallization of the title compound, C(26)H(24)FNO(6), which shows several differences compared with the starting compound. In the crystal structure of the title compound, intra- and inter-molecular hydrogen bonding is found. ...[more]

PMID: 21203252

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