Ontology highlight
ABSTRACT:
SUBMITTER: Hiby SE
PROVIDER: S-EPMC2964995 | biostudies-literature | 2010 Nov
REPOSITORIES: biostudies-literature
Hiby Susan E SE Apps Richard R Sharkey Andrew M AM Farrell Lydia E LE Gardner Lucy L Mulder Arend A Claas Frans H FH Walker James J JJ Redman Christopher W CW Morgan Linda L Tower Clare C Regan Lesley L Moore Gudrun E GE Carrington Mary M Moffett Ashley A
The Journal of clinical investigation 20101025 11
Many common disorders of pregnancy are attributed to insufficient invasion of the uterine lining by trophoblast, fetal cells that are the major cell type of the placenta. Interactions between fetal trophoblast and maternal uterine NK (uNK) cells--specifically interactions between HLA-C molecules expressed by the fetal trophoblast cells and killer Ig-like receptors (KIRs) on the maternal uNK cells--influence placentation in human pregnancy. Consistent with this, pregnancies are at increased risk ...[more]