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1-Formyl-r-2,c-6-bis-(4-methoxy-phen-yl)-c-3,t-3-dimethyl-piperidin-4-one.

ABSTRACT: In the title compound, C(22)H(25)NO(4), the piperidine ring adopts a distorted boat conformation. The two benzene rings are approximately perpendicular to each other, making a dihedral angle of 86.2 (8)°. The crystal packing is stabilized by C-H⋯O and C-H⋯π inter-actions.

SUBMITTER: Kavitha T

PROVIDER: S-EPMC2968915 | biostudies-literature |

REPOSITORIES: biostudies-literature

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1-Formyl-r-2,c-6-bis-(4-methoxy-phen-yl)-t-3,t-5-dimethyl-piperidin-4-one.

Project description:In the title compound, C(22)H(25)NO(4), the piperidine ring adopts a distorted boat conformation. The methyl groups at the 3 and 5 positions of the piperidine ring are in axial and equatorial orientations, respectively. Both H and O atoms in the aldehyde group are disordered over two positions with occupancies of 0.534?(5) and 0.466?(5). In the crystal, the mol-ecules are linked into a three-dimensional network by C-H?O hydrogen bonds.

| S-EPMC2971115 | biostudies-literature

1-Bromo-acetyl-2,6-bis-(4-methoxy-phen-yl)-3,5-dimethyl-piperidin-4-one.

Project description:In the title compound, C(23)H(26)BrNO(4), the piperidinone ring adopts a boat conformation. The dihedral angle between the two benzene rings is 70.9?(1)°. The two meth-oxy groups are close to coplanar with the attached benzene rings [C-C-O-C torsion angles of 6.3?(5) and 16.4?(4)°]. A weak C-H?Br intra-molecular inter-action is observed. In the crystal structure, mol-ecules are linked into a chain along [101] by inter-molecular C-H?O hydrogen bonds. A short inter-molecular Br?O contact [3.063?(2)?Å] is observed.

| S-EPMC2959452 | biostudies-literature

1-Chloro-acetyl-2,6-bis-(2-methoxy-phen-yl)-3,5-dimethyl-piperidin-4-one.

Project description:The piperidone ring in the title compound, C(23)H(26)ClNO(4), adopts a boat conformation with its two out-of-plane C atoms deviating by 0.597?(2) and 0.630?(2)?Å from the least-squares plane of the rest of atoms in the ring. The two aromatic rings are roughly perpendicular to each other, making a dihedral angle of 75.1?(1)°, and a C-H?? intra-molecular inter-action is observed. The crystal packing is stabilized by a C-H?O inter-molecular inter-action, generating a chain with a C(9) motif along the a axis.

| S-EPMC2970045 | biostudies-literature

1-Formyl-r-2,c-6-bis-(4-methoxy-phen-yl)-t-3-methyl-piperidin-4-one.

Project description:The asymmetric unit of the title compound, C(21)H(23)NO(4), contains two crystallographically independent mol-ecules A and B. In both mol-ecules, the piperidine-4-one rings adopt a distorted twist-boat conformation. The formyl group at position 1, the methoxy-phenyl ring at position 2 and the methyl group at position 3 are attached equatorially. The meth-oxy phenyl ring at position 6 has an axial orientation. The dihedral angle between the two benzene rings is 55.27?(8)° in mol-ecule A, and 55.29?(8)° in mol-ecule B. In the crystal, the mol-ecules are linked by weak C-H?O inter-molecular hydrogen-bond inter-actions. In addition, weak C-H?? inter-molecular inter-actions involving the benzene rings at positions 6 and 2 of mol-ecule B are also found in the crystal structure.

| S-EPMC2971181 | biostudies-literature

2,6-Bis(3-methoxy-phen-yl)-3-methyl-piperidin-4-one.

Project description:In the mol-ecule of the title compound, C(20)H(23)NO(3), the bulky methoxy-phenyl substituents at the equatorial 2,6-positions crowd the vicinity of the equatorial amino H atom and prevent it from forming inter-molecular hydrogen bonds. The piperidine ring adopts a distorted chair conformation.

| S-EPMC2972106 | biostudies-literature

r-2,c-6-Bis(3-methoxy-phen-yl)-t-3,t-5-dimethyl-piperidin-4-one.

Project description:In the title compound, C(21)H(25)NO(3), the piperidinone ring adopts a chair conformation with an equatorial orientation of all substituents; the 3-methoxy-phenyl groups make a dihedral angle of 60.26?(15)°. The carbonyl group O atom is disordered over two positions in a 0.643?(3):0.357?(3) ratio. The crystal structure is stabilized by N-H?O and C-H?O hydrogen bonding.

| S-EPMC2962197 | biostudies-literature

1-Chloro-acetyl-r-2,c-6-bis-(4-methoxy-phen-yl)-c-3,t-3-dimethyl-piperidin-4-one.

Project description:In the title compound, C(23)H(26)ClNO(4), the piperidine ring adopts a distorted boat conformation. The two methoxy-phenyl groups at the 2 and 6 positions of the piperidine ring are in axial and equatorial orientations. An intra-molecular C-H?Cl inter-action is observed. In the crystal, the mol-ecules are linked into zigzag chains along the b axis by C-H?? inter-molecular inter-actions.

| S-EPMC2971163 | biostudies-literature

r-2,c-6-Bis(2-methoxy-phen-yl)-t-3,t-5-dimethyl-piperidin-4-one acetic acid solvate.

Project description:In the title compound, C(21)H(25)NO(3)·C(2)H(4)O(2), the piperidone ring adopts a chair conformation. The two meth-oxy groups are nearly coplanar with the aromatic rings to which they are attached. The dihedral angle between the two aromatic rings is 60.9?(2)°. There are two short intra-molecular N-H?O contacts. The crystal packing is stabilized by inter-molecular O-H?N and C-H?O inter-actions.

| S-EPMC2979382 | biostudies-literature

1-Dichloro-acetyl-r-2,c-6-bis-(4-methoxy-phen-yl)-t-3,t-5-dimethyl-piperidin-4-one.

Project description:In the title compound, C(23)H(25)Cl(2)NO(4), the piperidine ring adopts a distorted boat conformation. The dihedral angle between the benzene rings is 54.8 (1)°. In the crystal, the mol-ecules are linked into a two-dimensional network parallel to the ab plane by C-H⋯O hydrogen bonds.

| S-EPMC2979939 | biostudies-literature

1-Dichloro-acetyl-r-2,c-6-bis-(4-methoxy-phen-yl)-c-3,t-3-dimethyl-piperidin-4-one.

Project description:In the title compound, C(23)H(25)Cl(2)NO(4), the piperidine ring adopts a distorted boat conformation. Inversion-related mol-ecules are linked into centrosymmetric R(2) (2)(16) dimers by paired C-H⋯O hydrogen bonds, and the dimers are connected via C-H⋯O hydrogen bonds into a chain running along [101].

| S-EPMC2967932 | biostudies-literature

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