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(S)-Methyl 2-[(3R,4R)-2-benzyl-3-(2-fur-yl)-1-oxo-1,2,3,4-tetra-hydro-isoquinoline-4-carboxamido]-3-(1H-indol-3-yl)propanoate.

ABSTRACT: The title compound, C(33)H(29)N(3)O(5), was synthesized by the reaction of racemic trans-2-benzyl-3-(2-fur-yl)-1-oxo-1,2,3,4-tetra-hydro-isoquinoline-4-carboxylic acid, l-tryptophan methyl ester and diisopropylcarbodiimide in dry dichloro-methane. The furan ring is disordered over two positions in a 0.859?(14):0.141?(14) ratio. In the 1,2,3,4-tetra-hydro-iso-quin-oline ring system, the heterocyclic ring is not planar, with puckering parameters Q(T) = 0.448?(2)?Å, ? = 64.9?(3) and ? = 268.3?(3)°. The crystal is extended into a three-dimensional supra-molecular architecture through inter-molecular N-H?O hydrogen bonds and C-H?? inter-actions. The absolute structure was assigned by reference to the chiral starting material.

SUBMITTER: Bakt?r Z

PROVIDER: S-EPMC2969238 | biostudies-literature | 2009 Jun

REPOSITORIES: biostudies-literature

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(S)-Methyl 2-[(3R,4R)-2-benzyl-3-(2-fur-yl)-1-oxo-1,2,3,4-tetra-hydro-isoquinoline-4-carboxamido]-3-(1H-indol-3-yl)propanoate.

Baktır Zeliha Z Akkurt Mehmet M Kandinska Meglena I MI Bogdanov Milen G MG Büyükgüngör Orhan O

Acta crystallographica. Section E, Structure reports online 20090606 Pt 7

The title compound, C(33)H(29)N(3)O(5), was synthesized by the reaction of racemic trans-2-benzyl-3-(2-fur-yl)-1-oxo-1,2,3,4-tetra-hydro-isoquinoline-4-carboxylic acid, l-tryptophan methyl ester and diisopropylcarbodiimide in dry dichloro-methane. The furan ring is disordered over two positions in a 0.859 (14):0.141 (14) ratio. In the 1,2,3,4-tetra-hydro-iso-quin-oline ring system, the heterocyclic ring is not planar, with puckering parameters Q(T) = 0.448 (2) Å, θ = 64.9 (3) and ϕ = 268.3 (3)°. ...[more]

PMID: 21582765

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