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(4R)-4-(Biphenyl-4-yl)-7-chloro-1,2,3,4-tetra-hydro-quinoline.

ABSTRACT: The title compound, C(21)H(18)ClN, was synthesized by an enanti-oselective Brønsted acid-catalysed transfer hydrogenation reaction. The six-membered heterocycle adopts a half-chair conformation. It has the biphenyl residue in an axial position. The two rings of the biphenyl residue are almost coplanar [dihedral angle = 2.65?(9)°]. The crystal packing is stabilized by N-H?Cl hydrogen bonds, which connect the mol-ecules into chains running along the a axis.

SUBMITTER: Theissmann T

PROVIDER: S-EPMC3201410 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature

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(4R)-4-(Biphenyl-4-yl)-7-chloro-1,2,3,4-tetra-hydro-quinoline.

Theissmann Thomas T Bolte Michael M

Acta crystallographica. Section E, Structure reports online 20110930 Pt 10

The title compound, C(21)H(18)ClN, was synthesized by an enanti-oselective Brønsted acid-catalysed transfer hydrogenation reaction. The six-membered heterocycle adopts a half-chair conformation. It has the biphenyl residue in an axial position. The two rings of the biphenyl residue are almost coplanar [dihedral angle = 2.65 (9)°]. The crystal packing is stabilized by N-H⋯Cl hydrogen bonds, which connect the mol-ecules into chains running along the a axis. ...[more]

PMID: 22064825

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