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3-(4-Fluoro-phen-yl)-2-(4-pyrid-yl)pyrido[2,3-b]pyrazine.

ABSTRACT: In the crystal structure of the title compound, C(18)H(11)FN(4), the pyridopyrazine ring makes dihedral angles of 34.67?(7) and 52.24?(7)° with the 4-fluoro-phenyl and pyridine rings, respectively. The 4-fluoro-phenyl ring makes a dihedral angle of 59.56?(9)° with the pyridine ring.

SUBMITTER: Koch P

PROVIDER: S-EPMC2970414 | biostudies-literature | 2009 Sep

REPOSITORIES: biostudies-literature

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3-(4-Fluoro-phen-yl)-2-(4-pyrid-yl)pyrido[2,3-b]pyrazine.

Koch Pierre P Schollmeyer Dieter D Laufer Stefan S

Acta crystallographica. Section E, Structure reports online 20090926 Pt 10

In the crystal structure of the title compound, C(18)H(11)FN(4), the pyridopyrazine ring makes dihedral angles of 34.67 (7) and 52.24 (7)° with the 4-fluoro-phenyl and pyridine rings, respectively. The 4-fluoro-phenyl ring makes a dihedral angle of 59.56 (9)° with the pyridine ring. ...[more]

PMID: 21577988

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2-(4-Fluoro-phen-yl)-3-(4-pyrid-yl)pyrido[2,3-b]pyrazine.

Project description:In the crystal structure of the title compound, C(18)H(11)FN(4), the pyridopyrazine system makes dihedral angles of 45.51?(7) and 44.75?(7)° with the attached 4-fluoro-phenyl ring and the pyridine ring, respectively. The 4-fluoro-phenyl ring makes a dihedral angle of 54.54?(8)° with the pyridine ring. The pyridine ring part of the pyridopyrazine ring and the pyrazine ring of two c-glide-plane-related mol-ecules form ?-? inter-actions. The angle between the planes is 2.09?(7)° and the distance between the centroids is 3.557?(1)Å.

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Project description:Crystals of the title compound, C(23)H(17)B(3)F(3)NO(3), were obtained unintentionally by slow evaporation of a chloro-form solution of the preformed boroxine-pyridine adduct. The mol-ecule contains three fluoro-substituted benzene rings, each bonded to one of the three B atoms of a six-membered boroxine ring. A pyridyl ring is also bound to one of the B atoms through a Lewis acid-base inter-action. The binding of the pyridyl substituent causes the otherwise planar boroxine ring to twist, resulting in a maximum torsion angle within the ring of 17.6 (2)°.

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Project description:In the title compound, C(11)H(6)Cl(2)FN, the dichloro-benzene and the 2-fluoro-pyridine rings are oriented at a dihedral angle of 47.73 (3)°. In the crystal, pairs of C-H⋯N inter-actions link the mol-ecules into dimers with R(2) (2)(12) motifs. Mol-ecules are arranged in stacks extending along [100] via π-π inter-actions with a centroid-centroid distance of 3.8889 (3) Å.

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6-(2,6-Dimethyl-phen-yl)pyrido[2,3-d]pyrimidin-7-amine.

Project description:In the title compound, C(15)H(14)N(4), the pyrido[2,3-d]pyrimidine system is almost ideally planar (r.m.s. deviation 0.028?Å) with its mean plane almost orthogonal to the 2,6-dimethyl-phenyl plane. The dihedral angle formed by these planes [87.3?(2)°] is close to the predicted value (89.7°) obtained by mol-ecular-mechanics force-field calculations. Only one of the two active amine H atoms participates in hydrogen bonding, which links mol-ecules into centrosymmetric dimers.

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